Mast cell involvement in inflammation, depression

The Science

More scientific evidence of the connection between mast cells, inflammation and depression from PubMed: Converging sources of evidence point to a role for inflammation in the development of depression, fatigue and cognitive dysfunction. More precisely, the tryptophan (TRP) catabolism is thought to play a major role in inflammation-induced depression. Mastocytosis is a rare disease in […]

February 18, 2017

Mast Cell Disease & Depression: Is Doxepin The Answer?

The Treatments

Chronic depression in mast cell disease patients is frequently seen both in mastocytosis and mast cell activation syndrome. When you understand the way mast cell disease works it’s easy to see why we as patients sometimes battle clinical levels of depression, among (many) other things. As a patient myself I have struggled off and on […]

February 2, 2017