Mast Cell Disease In The News: Two New Interesting Discoveries


The Science

A couple of interesting discoveries recently in the science and research aspect of mast cell disease starting with this piece about the relationship between mast cells and chronic urticaria (hives) from Australia: One in five people experience hives in their lifetime as an allergic reaction but a small number of people suffer hives, known as […]

July 16, 2017

Is A Cure For Mast Cell Disease On The Horizon??


The Science

When I read about the groundbreaking discovery which could offer a “cure for ALL allergies with a single treatment”, I got more than a little excited: Severe allergies could be ‘turned off’ by gene therapy, a new study has suggested. Researchers say a single treatment giving life-long protection from severe allergies such as asthma could […]

June 3, 2017

Mast Cell Driven (Non IgE) Chronic Allergic Inflammation


The Science

Many mast cell disease patients have allergy tests that come back negative, myself included, for things we are 100%  sure are triggering our “allergies”. It can be really frustrating for doctor and patient. It wasn’t until a few hours after I went home that three of my food allergy skin prick test spots formed hard, […]

May 5, 2017

Advanced Systemic Mastocytosis: A New Drug On The Horizon?


The Science

Here’s an interesting piece on recent research for a new drug to treat KIT positive patients with advanced systemic mastocytosis and mast cell leukemia. I’ve abridged to highlight the exciting parts: The Food and Drug Administration has approved only one drug, called imatinib, to treat advanced mastocytosis. Imatinib blocks the action of a cellular protein […]

February 21, 2017

A Brief History Of Mast Cell Disease


The Science

Aside from knowing what to eat, which doctors to see, which medicines to take and what symptoms are commonly seen in mast cell disorders of all types, have you ever wondered about the history of this little immune cell that (for many of us) is wreaking havoc in our lives? Here is a brief history […]

February 20, 2017

Mast cell involvement in inflammation, depression


The Science

More scientific evidence of the connection between mast cells, inflammation and depression from PubMed: Converging sources of evidence point to a role for inflammation in the development of depression, fatigue and cognitive dysfunction. More precisely, the tryptophan (TRP) catabolism is thought to play a major role in inflammation-induced depression. Mastocytosis is a rare disease in […]

February 18, 2017

Mast Cell Disease Research: Who? Where? When?


The Science

As a patient I am always curious where the research is at with mast cell disease. Are new medicines coming my way? Is a cure around the corner? Will I be able to eat cheesecake again?!! Probably not on the last one at least. I doubt I’ll ever have cheesecake again or even take part […]

February 16, 2017

Male Vs. Female Mast Cells: New Research


The Science

While mastocytosis seems to affect men and women equally, there are a lot of co-existing conditions that affect women at a much higher rate. Typically these are auto-immune and inflammatory diseases and doctors have been trying to figure out why these disorders are more prevalent in females than in males. Now there is some interesting […]

February 15, 2017